التفاصيل البيبلوغرافية
| العنوان: |
Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease. |
| المؤلفون: |
Bryant, Annie, Zhaozhi Li, Jayakumar, Rojashree, Serrano-Pozo, Alberto, Woost, Benjamin, Miwei Hu, Woodbury, Maya E., Wachter, Astrid, Lin, Gen, Taekyung Kwon, Talanian, Robert V., Biber, Knut, Karran, Eric H., Hyman, Bradley T., Das, Sudeshna, Bennett, Rachel E. |
| المصدر: |
Journal of Neuroscience; 6/14/2023, Vol. 43 Issue 24, p4541-4557, 17p |
| مصطلحات موضوعية: |
ALZHEIMER'S disease, ENDOTHELIAL cells, VASCULAR endothelial cells, AMYLOID plaque, CEREBRAL amyloid angiopathy, ENTORHINAL cortex |
| مستخلص: |
Vascular endothelial cells play an important role in maintaining brain health, but their contribution to Alzheimer's disease (AD) is obscured by limited understanding of the cellular heterogeneity in normal aged brain and in disease. To address this, we performed single nucleus RNAseq on tissue from 32 human AD and non-AD donors (19 female, 13 male) each with five cortical regions: entorhinal cortex, inferior temporal gyrus, prefrontal cortex, visual association cortex, and primary visual cortex. Analysis of 51,586 endothelial cells revealed unique gene expression patterns across the five regions in non-AD donors. Alzheimer's brain endothelial cells were characterized by upregulated protein folding genes and distinct transcriptomic differences in response to amyloid β plaques and cerebral amyloid angiopathy. This dataset demonstrates previously unrecognized regional heterogeneity in the endothelial cell transcriptome in both aged non-AD and AD brain. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
