التفاصيل البيبلوغرافية
| العنوان: |
Incidence of congenital complications related to COVID-19 infection during pregnancy. |
| المؤلفون: |
Reppucci, M.L., Kaizer, A.M., Prendergast, C., Acker, S.N., Mandell, E.W., Euser, A.G., Diaz-Miron, J. |
| المصدر: |
Journal of Neonatal - Perinatal Medicine; 2023, Vol. 16 Issue 2, p227-234, 8p |
| مصطلحات موضوعية: |
COVID-19 pandemic, COVID-19, LIMB reduction defects, CONGENITAL disorders, HUMAN abnormalities |
| مستخلص: |
PURPOSE: Infection with COVID-19 during pregnancy has been associated with a hypercoagulable state. It is unknown if maternal COVID-19 infection results in congenital anomalies secondary to intrauterine vascular accidents. This study sought to determine if the rate of in-utero vascular complications (intestinal atresia and limb abnormalities) that may be attributable to the hypercoagulable states associated with COVID-19 and pregnancy increased after the onset of the pandemic. METHODS: Pregnancy, neonatal, and congenital defect data from a single academic medical center and the partner's children's hospital were collected and compared to the period prior to onset of the pandemic. A subanalysis including pregnant woman 18 years or greater with documented COVID-19 infection during gestation between March 2020-2021 was performed. RESULTS: Rates of intestinal atresia did not differ prior to or after the onset of the pandemic (3.78% vs 7.23%, p = 0.21) nor did rates of limb deficiency disorders (4.41% vs 9.65%, p = 0.09). On subanalysis, there were 194 women with COVID-19 infection included in analysis: 135 (69.6%) were positive during delivery admission and 59 (30.4%) were positive earlier in their pregnancy. There was one infant born with intestinal atresia. CONCLUSION: We report a low incidence of congenital anomalies in infants born to mothers with COVID-19 infection. It remains unclear if the impact of COVID-19 on the coagulative state augments the normal pro-thrombotic state of pregnancy; ongoing surveillance is warranted. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
