التفاصيل البيبلوغرافية
| العنوان: |
SCG10 is required for peripheral axon maintenance and regeneration in mice. |
| المؤلفون: |
Yuanjun Li, Yonglu Tian, Xiayuhe Pei, Pengli Zheng, Linqing Miao, Lingjun Li, Chunxiong Luo, Peixun Zhang, Baoguo Jiang, Junlin Teng, Ning Huang, Jianguo Chen |
| المصدر: |
Journal of Cell Science; Jun2023, Vol. 136 Issue 12, p1-14, 14p |
| مصطلحات موضوعية: |
PERIPHERAL nervous system, AXONS, NERVOUS system regeneration, AXONAL transport, DORSAL root ganglia, SCIATIC nerve, NEUROLOGICAL disorders |
| مستخلص: |
Proper microtubule dynamics are critical for neuronal morphogenesis and functions, and their dysregulation results in neurological disorders and regeneration failure. Superior cervical ganglion-10 (SCG10, also known as stathmin-2 or STMN2) is a well-known regulator of microtubule dynamics in neurons, but its functions in the peripheral nervous system remain largely unknown. Here, we show that Scg10 knockout mice exhibit severely progressive motor and sensory dysfunctions with significant sciatic nerve myelination deficits and neuromuscular degeneration. Additionally, increased microtubule stability, shown by a significant increase in tubulin acetylation and decrease in tubulin tyrosination, and decreased axonal transport were observed in Scg10 knockout dorsal root ganglion (DRG) neurons. Furthermore, SCG10 depletion impaired axon regeneration in both injured mouse sciatic nerve and cultured DRG neurons following replating, and the impaired axon regeneration was found to be induced by a lack of SCG10-mediated microtubule dynamics in the neurons. Thus, our results highlight the importance of SCG10 in peripheral axon maintenance and regeneration. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
