التفاصيل البيبلوغرافية
| العنوان: |
A new flavonol derivative and other compounds from the leaves of Bauhinia thonningii Schum with activity against multidrug-resistant bacteria. |
| المؤلفون: |
Nouemsi, Guy Raphael Sado, Jouda, Jean-Bosco, Leutcha, Peron Bosco, Matieta, Valaire Yemene, Tsague Tankeu, Virginie Flaure, Ngnouzouba Kuete, Jenifer Reine, Çelik, İlhami, Kuete, Victor, Sewald, Norbert, Lannang, Alain Meli |
| المصدر: |
Natural Product Research; Aug/Sep2023, Vol. 37 Issue 16, p2653-2661, 9p |
| مصطلحات موضوعية: |
FLAVONOLS, BAUHINIA, METHICILLIN-resistant staphylococcus aureus, GRAM-negative bacteria, BACTERIA, ANTIBACTERIAL agents, GRAM-positive bacteria, MICROCOCCACEAE |
| مستخلص: |
Investigation of the leaves of Bauhinia thonningii Schum led to the isolation and identification of a new flavonol derivative, 6-C-methylquercetin-3,4'-dimethyl ether (1) together with eleven known compounds (2–13), with two of them (10 and 11) obtained as a mixture. Their structures were established by extensive spectroscopic analyses. Antibacterial activity of compound 1 as well as the reference antibiotic, ciprofloxacin was tested on Gram-negative multidrug-resistant bacteria overexpressing active efflux pumps, and against methicillin-resistant strains of Staphylococcus aureus (MRSA). Samples were tested alone and in combination with an efflux pump inhibitor (EPI), phenylalanine-arginine-β-naphthylamide (PAßN). Results show that when compound 1 was tested alone, its inhibitory effects were obtained on 7/10 tested bacteria with the highest MIC value of 128 µg/mL whilst in the presence of EPI, this activity significantly increase in all the 10 bacteria. An interesting antibacterial activity was obtained with compound 1 against Klebsiella pneumoniae ATCC11296 (MIC of 4 µg/mL), KP55 and Staphylococcus aureus MRSA6 in the presence of the PaßN. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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