التفاصيل البيبلوغرافية
| العنوان: |
Radiocomplexation, Biological Evaluation, and Characterization of [99mTc]-5-[(3-Carboxy-4-hydroxyphenyl)diazenyl]-2-hydroxybenzoic Acid as a Novel Agent for Imaging of Ulcerative Colitis in Mice. |
| المؤلفون: |
Sanad, M. H., Eyssa, H. M., Marzook, F. A., Farag, A. B., Elrefaei, A., Fouzy, A. S. M., Challan, S. B. |
| المصدر: |
Radiochemistry; Jun2023, Vol. 65 Issue 3, p378-386, 9p |
| مصطلحات موضوعية: |
ULCERATIVE colitis, THIN layer chromatography, HIGH performance liquid chromatography, RADIOCHEMICAL purification, MICE |
| مستخلص: |
A procedure was developed for preparing [99mTc]-tricarbonyl-5-[(3-carboxy-4-hydroxyphenyl)diazenyl]-2-hydroxybenzoic acid complex ([99mTc]-tricarbonyl-Olsalazine), for ulcerative colitis (UC) imaging. High yield and 98.5% radiochemical purity of [99mTc]-tricarbonyl-Olsalazine were reached under optimized conditions. Thin layer chromatography (TLC) was used for the purification of the labeled compound. Reversed-phase high-performance liquid chromatography (RP-HPLC) was also used. A biodistribution study performed with a microbial mouse model of UC showed that the colon localization of [99mTc]-tricarbonyl-Olsalazine was the highest (77 ± 1.7% ID/g) at 120 min post injection. The agent was still present in the ulcerated colon for up to 24 h post injection (75% ID/g). Such level was not reached in previous studies. Thus, [99mTc]-tricarbonyl-Olsalazine can be used as a radiotracer for UC imaging in mice. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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