التفاصيل البيبلوغرافية
| العنوان: |
The Exosome-Transmitted lncRNA LOC100132249 Induces Endothelial Dysfunction in Diabetic Retinopathy. |
| المؤلفون: |
Zizhong Hu, Jingfan Wang, Ting Pan, Xinsheng Li, Chao Tao, Yan Wu, Xingxing Wang, Zhengyu Zhang, Yu Liu, Weiwei Zhang, Changlin Xu, Xinjing Wu, Qinyuan Gu, Yuanyuan Fan, Huiming Qian, Aime Mugisha, Songtao Yuan, Qinghuai Liu, Ping Xie |
| المصدر: |
Diabetes; Sep2023, Vol. 72 Issue 9, p1307-1319, 13p |
| مستخلص: |
Diabetic retinopathy (DR), one of the most common microangiopathic complications in diabetes, causes severe visual damage among working-age populations. Retinal vascular endothelial cells, the key cell type in DR pathogenesis, are responsible for abnormal retinal angiogenesis in advanced stages of DR. The roles of exosomes in DR have been largely unknown. In this study, we report the first evidence that exosomes derived from the vitreous humor of patients with proliferative DR (PDR-exo) promote proliferation, migration, and tube formation of human retinal vascular endothelial cells (HRVECs). We identified long noncoding RNA (lncRNA) LOC100132249 enrichment in PDR-exo via high-throughput sequencing. This lncRNA, also mainly derived from HRVECs, promoted angiogenesis both in vitro and in vivo. Mechanistically, LOC100132249 acted as a competing endogenous sponge of miRNA-199a-5p (miR-199a-5p), thus regulating the endothelial-mesenchymal transition promoter SNAI1 via activation of the Wnt/β-catenin pathway and ultimately resulting in endothelial dysfunction. In conclusion, our findings underscored the pathogenic role of endothelial-derived exosomes via the LOC100132249/miR-199a-5p/SNAI1 axis in DR angiogenesis and may shed light on new therapeutic strategies for future treatment of DR. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
