التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic drugs: A comparison with commercially available polymers. |
| المؤلفون: |
Bansal, Kuldeep Kumar, Ali, Aliaa A., Rahman, Mijanur, Sjöholm, Erica, Wilén, Carl-Eric, Rosenholm, Jessica M. |
| المصدر: |
International Journal of Polymeric Materials & Polymeric Biomaterials; 2023, Vol. 72 Issue 16, p1272-1280, 9p |
| مصطلحات موضوعية: |
MICELLES, JASMINE, PHENYL group, FREE groups, FUNCTIONAL groups, POLYMERS |
| مستخلص: |
Achieving high solubilization capacity with the aid of polymeric micelles (PM) is still a major challenge. To address this shortcoming, novel poly(jasmine lactone) (PJL)-based PM were developed and compared with Soluplus® and poly(lactide) copolymer. The presence of "ene" groups on PJL's backbone offers a unique opportunity to insert functional groups. We introduced -COOH and phenyl groups onto the PJL copolymer and observed a ∼334-fold increment in aqueous solubility of clotrimazole with -COOH-terminated PJL copolymer compared to Soluplus. We thus successfully demonstrated that the presence of appropriate free functional groups on the polymer chain can facilitate the solubilization potential of PM. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Polymeric Materials & Polymeric Biomaterials is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
PDF full text from Publisher 
Full Text Finder