التفاصيل البيبلوغرافية
| العنوان: |
Effects of Plant-Based Extract Mixture on Alcohol Metabolism and Hangover Improvement in Humans: A Randomized, Double-Blind, Paralleled, Placebo-Controlled Clinical Trial. |
| المؤلفون: |
Jung, Seung Hee, Lee, Yun Ha, Lee, Eun Kyu, Park, Soo-Dong, Shim, Jae-Jung, Lee, Jung-Lyoul, Yoo, Hye Hyun |
| المصدر: |
Journal of Clinical Medicine; Aug2023, Vol. 12 Issue 16, p5244, 15p |
| مصطلحات موضوعية: |
HANGOVERS, BLOOD alcohol, POISONS, ALCOHOL dehydrogenase, ALCOHOL drinking |
| مستخلص: |
Hangovers are uncomfortable physiological symptoms after alcohol consumption caused by acetaldehyde, a toxic substance in which alcohol is metabolized by alcohol dehydrogenase (ADH). Rapid alcohol and acetaldehyde decomposition are essential to alleviate alcohol handling symptoms. This study investigated the effects of HY_IPA combined with Mesembryanthemum crystallinum, Pueraria lobata flower, and Artemisia indica on alleviating hangovers. A randomized, double-blind, parallel-group, placebo-controlled clinical study was conducted on 80 individuals with hangover symptoms. Alcohol intake was 0.9 g/bw with 40% whiskey, adjusted proportionately to body weight. The Acute Hangover Scale total score was 5.24 ± 5.78 and 18.54 ± 18.50 in the HY_ IPA and placebo groups, respectively (p < 0.0001). All nine indicators of the hangover symptom questionnaire were significantly improved in the HY_IPA group (p < 0.01). Blood alcohol and acetaldehyde concentrations rapidly decreased from 30 min in the HY_IPA group (p < 0.05). ADH and acetaldehyde dehydrogenase (ALDH) activities in the blood of the HY_IPA group were significantly higher than those in the placebo group at 0, 1, and 2 h after alcohol consumption (p < 0.01). The rapid hangover relief was due to increased ADH and ALDH. Therefore, HY_IPA effectively relieves hangover symptoms by decomposing alcohol and acetaldehyde when consumed before alcohol consumption. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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