التفاصيل البيبلوغرافية
| العنوان: |
Detailed characterization of Redondovirus in saliva of SARS-CoV-2-infected individuals in Sao Paulo, Brazil. |
| المؤلفون: |
Charlys da Costa, Antonio, Mendes-Correa, Maria C., Tozetto-Mendoza, Tania Regina, Villas-Boas, Lucy S., de Paula, Anderson Vicente, Paiao, Heuder Gustavo Oliveira, Leal, Fabio E., Ferreira, Noely E., Honorato, Layla, Leal, Elcio, Grandi, Giuliano, dos Santos Morais, Vanessa, Manuli, Erika R., Sabino, Ester C., Witkin, Steven S. |
| المصدر: |
PLoS ONE; 8/31/2023, Vol. 18 Issue 8, p1-10, 10p |
| مصطلحات موضوعية: |
SALIVA, COVID-19, TORQUE teno virus, DNA viruses, POLYMERASE chain reaction, SARS-CoV-2 |
| مصطلحات جغرافية: |
BRAZIL, SAO Paulo (Brazil) |
| مستخلص: |
Background: Redondovirus (ReDoV) is a DNA virus present in the respiratory tract of many healthy individuals. Since SARS-CoV-2, the virus responsible for COVID-19, also primarily infects the same site, we evaluated whether ReDoV was present at increased frequency in patients with COVID-19 and influenced infection parameters. Methods: Saliva samples were collected weekly from 59 individuals with COVID-19 and from 132 controls. ReDoV was detected by polymerase chain reaction and the genotypes were identified by metagenomics. Torque Teno Virus (TTV) in these samples were previously reported. Results: ReDoV was detected in saliva more frequently from COVID-19 patients (72.9%) than from controls (50.0%) (p = 0.0015). There were no associations between ReDoV detection and either continuous or intermittent SARS-CoV-2 shedding, the duration of SARS-CoV-2 detection in saliva, patients' sex or if infection was by the B1 or Gamma strain. The two ReDoV strains, Brisavirus and Vientovirus, were present in equivalent frequencies in ReDoV-positive COVID-19 patients and controls. Phylogenetic analysis suggested that the two ReDoV strains in Brazil were similar to strains previously detected on other continents. Conclusion: ReDoV expression in saliva is increased in males and females in Brazil with mild COVID-19 but its presence does not appear to influence properties of the SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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