التفاصيل البيبلوغرافية
| العنوان: |
Phytochemical constituents from Elsholtzia ciliata (Thunb.) Hyl. and their nitric oxide production inhibitory activities. |
| المؤلفون: |
Dung, Duong Thi, Hoang, Nguyen Huy, Yen, Duong Thi Hai, Yen, Pham Hai, Thu, Vu Kim, Dung, Nguyen Viet, Bang, Ngo Anh, Trang, Do Thi, Cuc, Nguyen Thi, Phan Thi Thanh, Huong, Tai, Bui Huu, Nhiem, Nguyen Xuan, Kiem, Phan Van |
| المصدر: |
Natural Product Research; 2023, Vol. 37 Issue 18, p3093-3102, 10p |
| مصطلحات موضوعية: |
CILIATA, NITRIC oxide, PREGNANE, CHEMICAL structure |
| مستخلص: |
A new megastigmane glycoside, (3S,4R,7E)-megastigma-5,7-diene-9-one-3,4-diol 3-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (1) and a new cyanogenic glycosyl derivative, (S)-2-(6′-O-R-rosmarinoyl-β-D-glucopyranosyloxy)-phenylacetonitrile (2) were isolated from the methanol extract of the Elsholtzia ciliata together with twelve known compounds, 1-O-β-D-glucopyranosyl-2-hydroxy-4-allylbenzene (3), citrusin C (4), 1,2-di-O-β-D-glucopyranosyl-4-allylbenzene (5), manglieside B (6), 4-allyl-2-hydroxyphenyl 1-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (7), (-)-isolariciresinol 3α-β-D-glucopyranoside (8), 7R,8R-threo-4,7,9-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-9′-O-β-D-glucopyranoside (9), 7R,8R-threo-4,7,9,9′-tetrahydroxy-3-methoxy-8-O-4′-neolignan-9′-O-β-D-glucopyranoside (10), cedrusin-4-O-β-D-glucopyranoside (11), icariside E3 (12), everlastoside L (13) and rosmarinic acid (14). Their chemical structures were elucidated on the basic of extensive 1D and 2D-NMR experiments, as well as their mass spectroscopic data. The absolute configurations of the compounds 1 and 2 were successfully indicated by both theoretical and calculated CD spectra. Compounds 3–7, 9 and 10 potential inhibited NO production in LPS-activated RAW264.7 cells with IC50 values of 6.71, 8.97, 12.38, 14.27, 16.13, 13.54, 16.27 µM, respectively, compared to that of the positive control of NG-monomethyl-L-arginine acetate (L-NMMA), IC50 = 32.51 µM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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