التفاصيل البيبلوغرافية
| العنوان: |
Axon guidance genes control hepatic artery development. |
| المؤلفون: |
Gannoun, Lila, De Schrevel, Catalina, Belle, Morgane, Dauguet, Nicolas, Achouri, Younes, Loriot, Axelle, Vanderaa, Christophe, Cordi, Sabine, Alexandra Dili, Heremans, Yves, Rooman, Ilse, Leclercq, Isabelle A., Jacquemin, Patrick, Gatto, Laurent, Lemaigre, Frédéric P. |
| المصدر: |
Development (09501991); Aug2023, Vol. 150 Issue 16, p1-15, 15p |
| مصطلحات موضوعية: |
HEPATIC artery, VASCULAR smooth muscle, EPHRIN receptors, BILE ducts, LIVER regeneration, GENE silencing, HOMEOSTASIS, AXONS |
| مستخلص: |
Earlier data on liver development demonstrated that morphogenesis of the bile duct, portal mesenchyme and hepatic artery is interdependent, yet how this interdependency is orchestrated remains unknown. Here, using 2D and 3D imaging, we first describe how portal mesenchymal cells become organised to form hepatic arteries. Next, we examined intercellular signalling active during portal area development and found that axon guidance genes are dynamically expressed in developing bile ducts and portal mesenchyme. Using tissue-specific gene inactivation in mice, we show that the repulsive guidance molecule BMP co-receptor A (RGMA)/neogenin (NEO1) receptor/ligand pair is dispensable for portal area development, but that deficient roundabout 2 (ROBO2)/ SLIT2 signalling in the portal mesenchyme causes reduced maturation of the vascular smooth muscle cells that form the tunica media of the hepatic artery. This arterial anomaly does not impact liver function in homeostatic conditions, but is associated with significant tissular damage following partial hepatectomy. In conclusion, our work identifies new players in development of the liver vasculature in health and liver regeneration. [ABSTRACT FROM AUTHOR] |
|
Copyright of Development (09501991) is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
