التفاصيل البيبلوغرافية
| العنوان: |
Daam2 phosphorylation by CK2α negatively regulates Wnt activity during white matter development and injury. |
| المؤلفون: |
Chih-Yen Wang, Zhongyuan Zuo, Juyeon Jo, Kyoung In Kim, Madamba, Christine, Qi Ye, Sung Yun Jung, Bellen, Hugo J., Hyun Kyoung Lee |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 8/29/2023, Vol. 120 Issue 35, p1-12, 22p |
| مصطلحات موضوعية: |
WHITE matter (Nerve tissue), CENTRAL nervous system, WNT signal transduction, PHOSPHORYLATION, MYELIN |
| مستخلص: |
Wnt signaling plays an essential role in developmental and regenerative myelination in the central nervous system. The Wnt signaling pathway is composed of multiple regulatory layers; thus, how these processes are coordinated to orchestrate oligodendrocyte (OL) development remains unclear. Here, we show CK2α, a Wnt/β-catenin signaling Ser/Thr kinase, phosphorylates Daam2, inhibiting its function and Wnt activity during OL development. Intriguingly, we found Daam2 phosphorylation differentially impacts distinct stages of OL development, accelerating early differentiation followed by decelerating maturation and myelination. Application toward white matter injury revealed CK2α-mediated Daam2 phosphorylation plays a protective role for developmental and behavioral recovery after neonatal hypoxia, while promoting myelin repair following adult demyelination. Together, our findings identify a unique regulatory node in the Wnt pathway that regulates OL development via protein phosphorylation-induced signaling complex instability and highlights a new biological mechanism for myelin restoration. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
