التفاصيل البيبلوغرافية
| العنوان: |
Short and Long-Term Prognostic Significance of Galectin-3 in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. |
| المؤلفون: |
Köktürk, Uğur, Püşüroğlu, Hamdi, Somuncu, Mustafa Umut, Akgül, Özgür, Uygur, Begüm, Özyılmaz, Sinem, Işıksaçan, Nilgün, Sürgit, Özgür, Yıldırım, Aydın |
| المصدر: |
Angiology; Oct2023, Vol. 74 Issue 9, p889-896, 8p |
| مصطلحات موضوعية: |
MORTALITY risk factors, CARDIOVASCULAR disease related mortality, PROTEINS, BIOMARKERS, PATIENT aftercare, PERCUTANEOUS coronary intervention, VENTRICULAR ejection fraction, MULTIVARIATE analysis, PATIENTS, PATIENT readmissions, ST elevation myocardial infarction, HOSPITAL admission & discharge, TREATMENT effectiveness, RISK assessment, DESCRIPTIVE statistics, HEART failure, PROPORTIONAL hazards models |
| مستخلص: |
This study evaluated the short and long-term prognostic value of galectin-3 in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). Patients (n = 143) were admitted with STEMI and followed up for 2 years. The study population was divided into high and low galectin-3 groups based on the admission median value of serum galectin-3. Primary clinical outcomes consisted of cardiovascular (CV) mortality, non-fatal reinfarction, stroke, and target vessel revascularization (TVR). CV events were recorded in hospital and at 1 and 2 years. The primary clinical outcomes (in-hospital, 1 year and 2 year) were significantly higher in the high galectin-3 group. (P =.008, P =.004, P =.002, respectively). High galectin-3 levels were also associated with heart failure development and re-hospitalization at both 1 year (P =.029, P =.009, respectively) and 2 years (P =.019, P =.036, respectively). According to Cox multivariate analysis, left ventricular ejection fraction (LVEF) was an independent predictor of 2-year cardiovascular mortality (P =.009), whereas galectin-3 was not (P =.291). Although high galectin-3 levels were not independent predictors of long-term CV mortality in patients with acute STEMI who underwent primary PCI, it was associated with short-term and long-term development of adverse CV events, heart failure, and re-hospitalization. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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