التفاصيل البيبلوغرافية
| العنوان: |
Ultrasonically Prepared Sodium Heparin-Stabilized Indocyanine Green/Nano-Hydroxyapatite Suspension for Collaborative Photodynamic and Photothermal Tumor Therapy. |
| المؤلفون: |
Song, Qifa, Ding, Zi-You, Li, Chengyu, Fan, Yiran, Tang, Xinli, Han, Yingchao |
| المصدر: |
Crystals (2073-4352); Sep2023, Vol. 13 Issue 9, p1387, 16p |
| مصطلحات موضوعية: |
HYDROXYAPATITE, REACTIVE oxygen species, SODIUM, INDOCYANINE green, INHIBITION of cellular proliferation, TUMOR growth |
| مستخلص: |
Indocyanine green (ICG) shows promise for diagnosing and treating tumors due to its good photothermal and fluorescent properties. In this study, sodium heparin (SH)-stabilized ICG/nano-hydroxyapatite (SH-ICG/nHAP) suspension was ultrasonically prepared to achieve photothermal and photodynamic collaborative therapy (PTT/PDT) for treating tumors. The nHAP had a short rod-like shape and a drug-loading capacity of 13.3% for ICG, corresponding to a drug-loading efficiency of 88.6%. In addition, the SH-ICG/nHAP suspension showed a very low release of ICG in PBS (7.4) and a slightly improved release in acidic buffers (6.5, 5.5), indicating an excellent binding ability of nHAP for ICG. The resulting SH-ICG/nHAP showed good suspension stability. Under an 808 nm near-infrared (NIR) laser, SH-ICG/nHAP showed good photothermal properties and could produce reactive oxygen species (ROS). Under the irradiation of an 808 nm NIR laser at 0.8 W/cm2 for 5 min, SH-ICG/nHAP was found to significantly inhibit HepG2 cells proliferation (78.58%), similar to free ICG. In vivo, SH-ICG/nHAP was found to exert an improved inhibitory effect on tumor growth compared to free ICG. Biocompatible and stable SH-ICG/nHAP suspension like this could be a promising system for the PTT/PDT of tumors. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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