التفاصيل البيبلوغرافية
| العنوان: |
Evolution of CRISPR/Cas Systems for Precise Genome Editing. |
| المؤلفون: |
Hryhorowicz, Magdalena, Lipiński, Daniel, Zeyland, Joanna |
| المصدر: |
International Journal of Molecular Sciences; Sep2023, Vol. 24 Issue 18, p14233, 15p |
| مصطلحات موضوعية: |
GENOME editing, CRISPRS, GENE therapy |
| مستخلص: |
The bacteria-derived CRISPR/Cas (an acronym for regularly interspaced short palindromic repeats/CRISPR-associated protein) system is currently the most widely used, versatile, and convenient tool for genome engineering. CRISPR/Cas-based technologies have been applied to disease modeling, gene therapies, transcriptional modulation, and diagnostics. Nevertheless, some challenges remain, such as the risk of immunological reactions or off-target effects. To overcome these problems, many new methods and CRISPR/Cas-based tools have been developed. In this review, we describe the current classification of CRISPR systems and new precise genome-editing technologies, summarize the latest applications of this technique in several fields of research, and, finally, discuss CRISPR/Cas system limitations, ethical issues, and challenges. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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