التفاصيل البيبلوغرافية
| العنوان: |
Clinical association study on the matrix metalloproteinase expression in the serum of patients with connective tissue disease complicated with interstitial lung disease. |
| المؤلفون: |
Hong Chen, Jun Tang, Juhua Liang, Dan Huang, Chunfeng Pan, Sha Liu, Xiuri Du, Liju Tao |
| المصدر: |
Archives of Rheumatology; Sep2023, Vol. 38 Issue 3, p367-374, 8p |
| مصطلحات موضوعية: |
BIOMARKERS, C-reactive protein, DISEASE progression, IMMUNOGLOBULINS, COMPLEMENT (Immunology), B cells, ACADEMIC medical centers, INTERSTITIAL lung diseases, CASE-control method, MATRIX metalloproteinases, CONNECTIVE tissue diseases, VITAL capacity (Respiration), COMPARATIVE studies, PEARSON correlation (Statistics), DESCRIPTIVE statistics, ENZYME-linked immunosorbent assay, BLOOD sedimentation, FORCED expiratory volume, PULMONARY function tests, RESEARCH funding, DATA analysis software, EARLY diagnosis, VENOUS puncture, DISEASE complications |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
Objectives: This study was implemented to reveal the expression and the clinical correlation of matrix metalloproteinases (MPSs) with connective tissue disease (CTD) complicated with interstitial lung disease (ILD). Patients and methods: This clinical study was conducted with 260 patients (151 males, 109 females; mean age: 47.3±12.5 years; range, 29 to 67 years) between October 2019 and October 2020. Among the subjects, 100 were CTD patients (CTD group), 80 were CTD patients with ILD (CTD-ILD group) and 80 were healthy individuals (control group). The MMP-2, -3, -7, and -9 levels in the serum of the three groups were detected by enzyme-linked immunosorbent assay. Results: Serum levels of MMP-3, -7, and -9 in the CTD-ILD group were higher, while the MMP-2 level was lower than those in the CTD group and the control group. The MMP-7 level in the serum of the CTD-ILD group was positively related to C-reactive protein, erythrocyte sedimentation rate, and rheumatoid factor and negatively correlated with immunoglobulin G and complement 3. The MMP-7 expression in the serum was positively correlated with forced expiratory volume in one second (FEV1%), FEV1/forced expiratory volume (FVC), and FVC in CTD-ILD patients. Pearson statistical analysis revealed that there was a significant positive correlation between the MMP-7 expression and the percentage of B cells in the serum of CTD-ILD patients. Conclusion: Expressions of MMP-3, -7, and -9 are significantly increased in the serum of patients with CTD and related interstitial lung lesions, and the high expression of MMP-7 indicates dynamic lung lesions, which is possible to be used as a possible biomarker for early diagnosis and assessment of disease progression. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
