التفاصيل البيبلوغرافية
| العنوان: |
Can PSMA PET/CT help in dose-tailoring in postprostatectomy radiotherapy? |
| المؤلفون: |
Champion, Ambroise, Zwhalen, Daniel Rudolf, Oehler, Christoph, Taussky, Daniel, Kroeze, Stephanie G. C., Burger, Irene A., Benzaquen, David |
| المصدر: |
Frontiers in Oncology; 2023, p1-6, 6p |
| مصطلحات موضوعية: |
RADIOTHERAPY |
| مستخلص: |
There are few randomized trials to evaluate the use of PSMA-PET in the planning of post-prostatectomy radiotherapy. There are two unresolved questions 1) should we increase the dose to lesions visible on PSMA-PET 2) can we reduce dose in the case of a negative PSMA-PET. In this review, we summarize and discuss the available evidence in the literature. We found that in general, there seems to be an advantage for dose-increase, but ta large recent study from the pre-PSMA era didn’t show an advantage for dose escalation. Retrospective studies have shown that conventional doses to PSMA-PET-positive lesions seem sufficient. On the other hand, in the case of a negative PSMA-PET, there is no evidence that dose-reduction is possible. In the future, the combination of PSMA-PET with genomic classifiers could help in better identify patients who might benefit from either dose- de-or -increase. We further need to identify intraindividual references to help identify lesions with higher aggressiveness. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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