التفاصيل البيبلوغرافية
| العنوان: |
Anti-carbamylated protein antibodies positivity and disease activity in Hispanic patients with established rheumatoid arthritis: An observational study. |
| المؤلفون: |
Vega-Morales, David, Garza-Elizondo, Mario A., Trouw, Leendert A., Gonzalez-Torres, Karina I., Torres-Lopez, Ernesto, Eguia-Bernal, Miryam, Loredo-Alanis, Salvador A., Gracia-Arechiga, Tayde S., Vazquez-Fuentes, Brenda R., Castañeda-Martinez, Diana D., Castañda-Martinez, Martha M., Elizondo-Solis, Cesar V., Mendiola-Jimenez, Andres, Salinas-Carmona, Mario C., Herrera-Sandate, Pablo, Cardenas-de la Garza, Jesus A., Rodriguez-Sanchez, Gerardo E., Galarza-Delgado, Dionicio A. |
| المصدر: |
Modern Rheumatology; Mar2022, Vol. 32 Issue 2, p330-337, 8p |
| مستخلص: |
Objectives: We aimed to determine the prevalence of anti-carbamylated protein (anti-CarP) antibodies in Mexican Hispanics with established rheumatoid arthritis (RA) and to assess their relationship with disease activity. Methods: A cohort study was conducted in 278 patients with established RA during an 18-month follow-up. We measured IgG/IgM/IgA rheumatoid factor (RF), IgG anticitrullinated protein antibodies (ACPA) and IgG/IgM/IgA anti-CarP antibodies using enzyme-linked immunosorbent assay (ELISA). For disease activity, we performed the 28-joint disease activity score with erythrocyte sedimentation rate (DAS28-ESR). Repeated measures one-way ANOVA was used to test the association between anti-CarP IgG antibody status and longitudinal DAS28-ESR scores. Patients were evaluated at baseline and at 6, 12, and 18 months during follow-up. Results: Anti-CarP IgG antibodies were positive in 47.8% of patients and, accounting for all isotypes, in 9.5% of patients with negative RF and ACPA. Triple antibody positivity was present in 42.6% of patients in our sample. Anti-CarP IgG antibody positivity did not show statistically significant differences in mean DAS28-ESR when compared to anti-CarP IgG antibody negative patients at baseline, 6, 12 or 18 months. Conclusion: Anti-CarP IgG antibodies are not associated to a higher disease activity in Hispanic patients with established RA. Our findings suggest that the clinical value of measuring anti-CarP anti-bodies in RA diminishes over time. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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