التفاصيل البيبلوغرافية
| العنوان: |
Cytotoxic phenyl polyketides from Hypericum curvisepalum N. Robson. |
| المؤلفون: |
He, Qiu-Ying, Zeng, Hong, Zhang, Qiu-Lan, Qin, Guan-Fang, Wang, He-Bin, Teng, Li-Ping, Zhou, Zhong-Bo |
| المصدر: |
Natural Product Research; Nov/Dec2023, Vol. 37 Issue 22, p3815-3820, 6p |
| مصطلحات موضوعية: |
POLYKETIDES, HYPERICUM, CYTOTOXINS, HEPATOCELLULAR carcinoma, CELL cycle, ENANTIOMERS |
| مستخلص: |
(±)-Hypecurvone A (1) and B (2), two new undescribed phenyl polyketides, along with seven known analogues (3–9) were isolated from the whole plant of Hypericum curvisepalum. Chiral separation of 1 and 2 yielded two pairs of enantiomers 1a/1b and 2a/2b, respectively. The structures of these compounds were elucidated by extensive spectroscopic analyses and ECD spectra simulations. All isolates exhibited moderate cytotoxicity against human hepatocellular carcinoma SMMC-7721 cells, and compound 3 also showed weak cytotoxicity toward MGC-803 cells. The cytotoxicity of these compounds was found to be related to enhanced mitochondria-mediated apoptosis and inhibition of the G2/M phase of the cell cycle. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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