التفاصيل البيبلوغرافية
| العنوان: |
Facile and stereospecific synthesis of diverse β-N-glycosyl sulfonamide scaffolds via palladium catalysis. |
| المؤلفون: |
Zhong, Lei, Wang, Qunliang, Wang, Yujuan, Cheng, Yiyang, Xiong, Yimeng, Peng, Haibo, Zhou, Zhen, He, Yun, Dai, Yuanwei |
| المصدر: |
Chemical Communications; 11/7/2023, Vol. 59 Issue 86, p12907-12910, 4p |
| مصطلحات موضوعية: |
SULFONAMIDES, DRUG discovery, PALLADIUM, SYNTHETIC products, CATALYSIS |
| مستخلص: |
Glycosylation is an important strategy to improve the druggability of lead compounds. Here, we present a palladium-catalysed stereospecific N-glycosylation of sulfonamides. This approach stands out with wide substrate scope, high functional group tolerance, and easy scalability, furnishing a broad spectrum of densely functionalized β-N-glycosyl sulfonamides with good efficiency and exceptional regio-/stereoselectivity. Diverse drug-like glycosulfonamido scaffolds have been constructed via a late-stage diversification strategy and various facile synthetic transformations of the products. Collectively, the established protocol provides a valuable tool for efficiently preparing glycosyl sulfonamides to facilitate drug discovery. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
