التفاصيل البيبلوغرافية
| العنوان: |
A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice. |
| المؤلفون: |
O'Keeffe, Maria, Oterhals, Åge, Weishaupt, Hrafn, Leh, Sabine, Ulvik, Arve, Ueland, Per Magne, Halstensen, Alfred, Marti, Hans-Peter, Gudbrandsen, Oddrun Anita |
| المصدر: |
European Journal of Nutrition; Dec2023, Vol. 62 Issue 8, p3227-3240, 14p |
| مصطلحات موضوعية: |
OBESITY complications, EXPERIMENTAL design, ALBUMINS, BIOCHEMISTRY, NEPHROTIC syndrome, ANIMAL experimentation, KIDNEY tubules, T-test (Statistics), FISHES, RESEARCH funding, DATA analysis software, DIETARY proteins, ANIMALS, MICE, KIDNEY glomerulus, ALBUMINURIA, DISEASE risk factors |
| مستخلص: |
Purpose: The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish proteins would attenuate or delay the development of glomerular hypertrophy (glomerulomegaly), mesangial sclerosis and albuminuria in obese BTBR ob/ob mice. Methods: Obese BTBR.CgLepob/WiscJ male mice were fed diets containing 25% of protein from Atlantic cod backbones and 75% of protein from casein (Cod-BB group), or casein as the sole protein source (control group). Kidneys were analysed morphologically, and markers for renal dysfunction were analysed biochemically in urine and serum. Results: The Cod-BB diet attenuated the development of mesangial sclerosis (P 0.040) without affecting the development of glomerular hypertrophy and albuminuria. The urine concentration of cystatin C (relative to creatinine) was lower in mice fed the Cod-BB diet (P 0.0044). Conclusion: A diet containing cod backbone protein powder attenuated the development of mesangial sclerosis and tubular dysfunction in obese BTBR ob/ob mice, but did not prevent the development of glomerular hypertrophy and albuminuria in these mice. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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