التفاصيل البيبلوغرافية
| العنوان: |
生长分化因子 5 诱导间充质干细胞多向分化的作用与问题. (Chinese) |
| Alternate Title: |
Effects and problems of growth differentiation factor 5-induced multidirectional differentiation of mesenchymal stem cells. (English) |
| المؤلفون: |
李飞非, 邓 江 |
| المصدر: |
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu; 7/8/2024, Vol. 28 Issue 19, p3084-3089, 6p |
| مصطلحات موضوعية: |
GROWTH differentiation factors, ENDOCHONDRAL ossification, BONE morphogenetic proteins, MESENCHYMAL stem cell differentiation, CARTILAGE regeneration, INTERVERTEBRAL disk, NUCLEUS pulposus, BONE regeneration |
| Abstract (English): |
BACKGROUND: Growth differentiation factor 5, a member of the transforming growth factor-β superfamily and bone morphogenetic protein family, plays an important role in articular cartilage injury repair, bone regeneration, improvement of intervertebral disc degeneration, tendon healing, and neurodevelopment. OBJECTIVE: To review the research progress of growth differentiation factor 5 in inducing chondrocytes, nucleus pulposus-like cells, tendon cell differentiation, as well as inducing bone formation and neurodevelopment. METHODS: The search terms “growth differentiation factor 5, articular cartilage, bone, nucleus pulposus cells, tendon, nerve regeneration” were used in CNKI, WanFang and PubMed. According to the inclusion and exclusion criteria, the articles not related to the subject matter were excluded and 69 articles related to growth differentiation factor 5 were included. RESULTS AND CONCLUSION: (1) Growth differentiation factor 5 can induce chondrogenic and osteoblastic differentiation of mesenchymal stem cells, but the concentration boundary of growth differentiation factor 5 to induce chondrogenic or osteoblastic differentiation remains unclear. (2) Growth differentiation factor 5 can induce mesenchymal stem cells to differentiate into nucleus pulposus cells, which may play a role in the treatment of intervertebral disc degeneration. (3) Growth differentiation factor 5 can induce mesenchymal stem cells to differentiate into tendon cells and play an important role in tendon repair and prevention of postoperative tendon adhesion. (4) Growth differentiation factor 5 can induce neurodevelopment and promote nerve regeneration. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
背景: 生长分化因子5属于转化生长因子β超家族成员和骨形态发生蛋白家族成员之一, 在关节软骨损伤修复、骨再生、改善椎间盘退行 性变、肌腱愈合和神经发育等方面发挥重要作用. 目的: 综述生长分化因子5诱导软骨细胞、髓核样细胞、肌腱细胞分化以及诱导骨形成和神经发育方面的研究进展. 方法: 在中国知网、万方数据库, 以“生长分化因子5, 关节软骨, 骨, 髓核样细胞, 肌腱, 神经再生”为检索词; 在PubMed数据库以 “growth differentiation factor 5, articular cartilage, bone, nucleus pulposus cells, tendon, nerve regeneration”为检索词进行检索. 根据 纳入与排除标准, 排除与主题内容不相关的文献, 纳入与生长分化因子5相关的69篇文献. 结果与结论: ①生长分化因子5可诱导间充质干细胞成软骨和成骨分化, 但是生长分化因子5诱导成软骨或成骨分化的浓度分界仍然不清 楚; ②生长分化因子5可诱导间充质干细胞向髓核细胞分化, 可能对治疗椎间盘退行性变有一定作用; ③生长分化因子5能够诱导间充质干 细胞向肌腱细胞分化, 对肌腱损伤修复及预防术后肌腱粘连发挥重要作用; ④生长分化因子5可诱导神经发育, 促进神经再生. [ABSTRACT FROM AUTHOR] |
|
Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
