التفاصيل البيبلوغرافية
| العنوان: |
Identification and characterization of a conserved outer-membrane protein of Neisseria gonorrhoeae. |
| المؤلفون: |
Judd, R. C., Strange, J. C., Pettit, R. K., Shafer, W. M. |
| المصدر: |
Molecular Microbiology; May1991, Vol. 5 Issue 5, p1091-1096, 6p, 1 Chart |
| مصطلحات موضوعية: |
PEPTIDOGLYCANS, NEISSERIA gonorrhoeae, PROTEINS, PENICILLIN, CARRIER proteins |
| مستخلص: |
A previous study in our laboratory identified a surface-exposed peptidoglycan-associated protein of Neisseria gonorrhoeae which had an apparent molecular mass of 44000 daltons (44kDa) (Hill and Judd, 1989). This paper reports results which confirm that the 44 kDa protein is surface-exposed, and that the protein is expressed in, and is structurally invariant among, 14 stains of N. gonorrhoeae. The fact that the 44 kDa outer-membrane protein is found in a conserved form in all gonococci examined strong suggests that it is crucial to the bacterium's survival. Moreover, it appears that this protein is a penicillin-binding protein (PBP3) (Shafer and Judd, 1991). This invariant, surface-exposed, peptidoglycan-associated outer-membrane protein deserves further investigation to elucidate its role in the immunobiology of N. gonorrhoeae, and its possible use as an immunoprophylactic reagent. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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