التفاصيل البيبلوغرافية
| العنوان: |
On-demand Versus Continuous Maintenance Treatment With a Proton Pump Inhibitor for Mild Gastroesophageal Reflux Disease: A Prospective Randomized Multicenter Study. |
| المؤلفون: |
Da Hyun Jung, Young Hoon Youn, Hye-Kyung Jung, Seung Young Kim, Cheal Wung Huh, Cheol Min Shin, Jung-Hwan Oh, Kyu Chan Huh, Moo In Park, Suck Chei Choi, Ki Bae Kim, Seon-Young Park, Joong Goo Kwon, Yu Kyung Cho, Jung Ho Park, Jeong Eun Shin, Eun Jeong Gong, Jae Hak Kim, Su Jin Hong, Hyun Jin Kim |
| المصدر: |
Journal of Neurogastroenterology & Motility; Oct2023, Vol. 29 Issue 4, p460-469, 10p |
| مصطلحات موضوعية: |
PROTON pump inhibitors, GASTROESOPHAGEAL reflux, CONTINUOUS groups, QUALITY of life, SATISFACTION |
| مستخلص: |
Background/Aims It remains unclear which maintenance treatment modality is most appropriate for mild gastroesophageal reflux disease (GERD). We aimed to compare on-demand treatment with continuous treatment using a proton pump inhibitor (PPI) in the maintenance treatment for patients with non-erosive GERD or mild erosive esophagitis. Methods Patients whose GERD symptoms improved after 4 weeks of standard dose PPI treatment were prospectively enrolled at 25 hospitals. Subsequently, the enrolled patients were randomly assigned to either an on-demand or a continuous maintenance treatment group, and followed in an 8-week interval for up to 24 weeks. Results A total of 304 patients were randomized to maintenance treatment (continuous, n = 151 vs on-demand, n = 153). The primary outcome, the overall proportion of unwillingness to continue the assigned maintenance treatment modality, failed to confirm the noninferiority of on-demand treatment (45.9%) compared to continuous treatment (36.1%). Compared with the on-demand group, the GERD symptom and health-related quality of life scores significantly more improved and the overall satisfaction score was significantly higher in the continuous treatment group, particularly at week 8 and week 16 of maintenance treatment. Work impairment scores were not different in the 2 groups, but the prescription cost was less in the on-demand group. Serum gastrin levels significantly elevated in the continuous treatment group, but not in the on-demand group. Conclusions Continuous treatment seems to be more appropriate for the initial maintenance treatment of non-erosive GERD or mild erosive esophagitis than on-demand treatment. Stepping down to on-demand treatment needs to be considered after a sufficient period of continuous treatment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
