التفاصيل البيبلوغرافية
| العنوان: |
Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of longterm metformin and liraglutide treatment. |
| المؤلفون: |
Ivić, Vedrana, Zjalić, Milorad, Blažetić, Senka, Fenrich, Matija, Labak, Irena, Scitovski, Rudolf, Szűcs, Kálmán Ferenc, Ducza, Eszter, Tábi, Tamás, Bagamery, Fruzsina, Szökő, Éva, Vuković, Rosemary, Rončević, Alen, Mandić, Dario, Debeljak, Željko, Berecki, Monika, Balog, Marta, Seres-Bokor, Adrienn, Sztojkov-Ivanov, Anita, Hajagos-Tóth, Judit |
| المصدر: |
Frontiers in Endocrinology; 2023, p1-22, 22p |
| مصطلحات موضوعية: |
HIGH-fat diet, METABOLIC syndrome, LIRAGLUTIDE, METFORMIN, WEIGHT gain, SUCROSE, FRUCTOSE, FAT |
| مستخلص: |
Aim/Introduction: The study aimed to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet (HFHSD) in both sexes. Methods: Elderly Sprague-Dawley rats, 45 weeks old, were randomized into four groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and two groups fed the HFHSD along with long-term treatment of either metformin (HFHSD+M) or liraglutide (HFHSD+L). Antidiabetic treatment started 5 weeks after the introduction of the diet and lasted 13 weeks until the animals were 64 weeks old. Results: Unexpectedly, HFHSD-fed animals did not gain weight but underwent significant metabolic changes. Both antidiabetic treatments produced sexspecific effects, but neither prevented the onset of prediabetes nor diabetes. Conclusion: Liraglutide vested benefits to liver and skeletal muscle tissue in males but induced signs of insulin resistance in females. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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