التفاصيل البيبلوغرافية
| العنوان: |
Formulation and Comparison of Topical Dosage Forms Containing P-Herbo Extract for Acne Therapy. |
| المؤلفون: |
Naveen, N. Raghavendra, K. S., Keerthiraj, Gaganashree, Biju, Prajitha, H. V., Annegowda, S. M., Sindhoor |
| المصدر: |
International Journal of Pharmaceutical Investigation; Oct-Dec2023, Vol. 13 Issue 4, p747-753, 7p |
| مصطلحات موضوعية: |
NEEM, CUTIBACTERIUM acnes, ACNE, CENTELLA asiatica, ANTIOXIDANTS, EXTRACTS |
| مستخلص: |
The objective of the present was to formulate a novel topical P-herbo dosage form by incorporating the extracts of Azadirachta indica, Centella asiatica, and Ocimum gratissum and compare the efficacy. There is a strong clinical need to establish an appropriate formulation with the possibility to treat Ance by once-a-day application. Topical P-herbo dosage forms were prepared using various concentrations of extracts, with other excipients, and were evaluated for physicochemical parameters such as Viscosity, pH, spreadability, and extrudability to determine the suitability of the topical formulation. Anti-oxidant activity by DPPH assay, anti-microbial assay against Cutibacterium acne, and in vitro skin irritation studies were also carried out. Studies revealed, in vitro skin irritation showed the least irritation score for formulations (Gels-0.2; cream and ointment- 0.3) compared to 1% clindamycin and positive control. On analyzing the results, the OF-2 formulation was found to be optimized, due to its good anti-microbial, antioxidant activity with high skin deposition of herbs extract. Further, the optimized formulation was subjected to stability studies in compliance with ICH guidelines for a period of six months and all evaluated parameters remained intact even after six months, thus confirming the stability of the formulation. Hence, the present research concludes that the ointment formulation containing P-herbo extract showed prolonged action and was an excellent substitute for synthetic antiacne formulations with once-daily application. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
