دورية أكاديمية

A case that developed acute generalized exanthematous pustulosis after hydroxychloroquine use and did not follow the ordinary healing process despite drug discontinuation.

التفاصيل البيبلوغرافية
العنوان: A case that developed acute generalized exanthematous pustulosis after hydroxychloroquine use and did not follow the ordinary healing process despite drug discontinuation.
Alternate Title: Hidroksiklorokin kullanımından sonra akut generalize ekzantematöz püstüloz gelişen ve ilaç kesilmesine rağmen olağan iyileşme sürecini takip etmeyen bir olgu. (Turkish)
المؤلفون: Kızıltepe, Melih, Kökoğlu, Emel Oğuz, Eldemir, Yasemin Özden, Şaş, Senem, Şenel, Abdurrahman Soner
المصدر: Journal of Turkish Society for Rheumatology; 2023, Vol. 15 Issue 3, p171-174, 4p
Abstract (English): Acute generalized exanthematous pustulosis is a disease that usually presents with sudden onset and widespread rash over the body. It is a condition characterized by non-follicular, sterile pustules that develop acutely with a base of edematous erythema. Acute generalized exanthematous pustulosis is usually drug-related, and hydroxychloroquine, an antimalarial drug frequently used in rheumatology practice, is one of the rare causes of acute generalized exanthematous pustulosis. Generally, spontaneous regression is expected after drug discontinuation. A sixty-year-old female patient developed acute generalized exanthematous pustulosis while receiving hydroxychloroquine. Despite drug discontinuation and steroid treatment, the lesions were persistent. The patient was treated with methotrexate and the lesions had resolved. It is aimed to raise awareness of the rare hydroxychloroquine-acute generalized exanthematous pustulosis relationship and its treatment with methotrexate by presenting this case. [ABSTRACT FROM AUTHOR]
Abstract (Turkish): Akut generalize ekzantematöz püstüloz, genellikle ani başlangıçlı ve tüm vücutta yaygın döküntülerle seyreden bir hastalıktır. Ödemli eritem zemininde akut gelişen, steril püstüllerle karakterize bir durumdur. Genellikle ilaca bağlıdır ve romatoloji pratiğinde sıklıkla kullanılan hidroksiklorokin, akut generalize ekzantematöz püstülozun nadir nedenlerinden biridir. Genellikle ilaç kesildikten sonra spontan gerileme beklenir. Altmış yaşında bir kadın hastada hidroksiklorokin tedavisi sırasında akut generalize ekzantematöz püstüloz gelişti. İlaç kesilmesine ve steroid tedavisine rağmen lezyonlar dirençliydi. Bunun üzerine methotrexate başlanan hastanın tedaviyle lezyonları tamamen geriledi. Bu olgu sunumu ile nadir görülen hidroksiklorokin-akut jeneralize ekzantematöz püstüloz ilişkisi ve metotreksat ile tedavisi konusunda farkındalık yaratmak amaçlanmıştır. [ABSTRACT FROM AUTHOR]
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قاعدة البيانات: Complementary Index
الوصف
تدمد:26512653
DOI:10.4274/raed.galenos.2023.46855