التفاصيل البيبلوغرافية
| العنوان: |
Prevalence of Anemia and its Relation with Shwachman Score in Children with Cystic Fibrosis. |
| المؤلفون: |
Afifi, Mona, Hassanzad, Maryam, Malek, Fatemeh, Kamfar, Sharareh, Pourabdollah, Mihan, Farnia, Poopak, Baghaei, Nooshin, Valinejadi, Ali, Velayati, Ali Akbar |
| المصدر: |
Tanaffos; 2023, Vol. 22 Issue 1, p160-166, 7p |
| مصطلحات موضوعية: |
CYSTIC fibrosis, VITAMIN D deficiency, ANEMIA, VITAMIN deficiency, VITAMIN D, FIBRODYSPLASIA ossificans progressiva |
| مستخلص: |
Background: Cystic fibrosis is a chronic and progressive genetic disease with a worldwide prevalence. As the disease progresses, symptoms develop, and make its management more challenging. Accumulating evidence suggests that early diagnosis of CF can significantly contribute to preventing reported nutritional problems including anemia, vitamin deficiencies, and hypoalbuminemia. This cross-sectional study was conducted to assess disease severity in cystic fibrosis patients using the Shwachman-Kulczycki score, as well as to determine its relation with anemia and vitamin D deficiency. Materials and Methods: Clinical and CF-related laboratory data were collected from the medical records of 57 CF patients with a definitive diagnosis. At the time of diagnosis, physicians performed simultaneous, blood sampling and scoring of patients using the Shwachman scoring system. Results: The mean age of patients was 16.12±6.48 years. Total scores of 86-100, 71-85, 56-70, 41-55, and <40, were reported in 5.4%, 7.1%, 14.3%, 14.3%, and 58.9% of CF patients, respectively. A significant correlation was found between disease severity and patients' age (P=0.02). The analysis also showed that the disease severity was significantly higher in anemic patients when compared to non-anemics (p =0.006). Based on the results, 33 patients with normochromic, 11 patients with microcytic, and 6 patients with macrocytic anemia were diagnosed in this study. We did not find a significant difference between disease severity and vitamin D levels (P=0.150). Conclusion: The scoring system used in the current study could reflect properly the clinical status of CF patients. However, simultaneous use of various methods using a larger sample size for comparison of results is suggested to improve the accuracy of findings. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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