التفاصيل البيبلوغرافية
| العنوان: |
Prevalence and Metabolic Characteristics of Patients with Latent Autoimmune Diabetes in Adults: A Cross-Sectional Study. |
| المؤلفون: |
Mehranpoor, Mahdieh, Mohammadi, Malihe, Lagzian, Milad |
| المصدر: |
Clinical Diabetology; 2023, Vol. 12 Issue 6, p362-369, 8p |
| مصطلحات موضوعية: |
AUTOIMMUNE disease treatment, TREATMENT of diabetes, GLUTAMIC acid, DISEASE prevalence, ENZYME-linked immunosorbent assay |
| مستخلص: |
Objective: To evaluate the frequency of autoantibodies to glutamic acid decarboxylase-65 (GADA) and tyrosine phosphatase (IA-2A) in adult patients diagnosed with type 2 diabetes (T2D) and its associated characteristics, in particular those that related to metabolic syndrome. Materials and methods: In this cross-sectional study, autoantibodies to GADA and IA-2A were measured in 384 adult patients with T2D. Assays for autoantibodies were conducted using ELISA kits. The sociodemographic, clinical, and metabolic characteristics of islet autoantibody-positive and negative participants were then compared. SPSS software was used for data analysis and p < 0.05 was selected as a significant level. Results: Thirty two (8.3%) participants were positive for at least one islet autoantibody. The prevalence of GADA and IA-2A were reported 6.3% and 2.3% respectively, and one patient had both antibodies together. Autoantibody-positive patients were significantly younger (p < 0.001), had lower median age at diagnosis (p = 0.010), mean body mass index (BMI) (p = 0.004), waist circumference (WC) (p = 0.033), total cholesterol (p = 0.020), triglycerides (p = 0.041), C-peptide (p < 0.001) and prevalence of metabolic syndrome (p < 0.001) and higher fasting blood glucose (FBG) (p = 0.046), glycated hemoglobin (HbA1c) levels (p = 0.035) and need for insulin therapy (p < 0.001) than patients with T2D. Sex distribution, blood pressure levels and family history of diabetes were similar in the two groups. Conclusions: The prevalence of LADA in the studied population was 8.3%. LADA should be suspected in leaner patients with T2D with worse glycemic control, low C-peptide level and without metabolic syndrome. Antibody screening is recommended to discriminate of LADA and to help better control of glycemic profile. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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