التفاصيل البيبلوغرافية
| العنوان: |
Mesenchymal stem cells and cancer‐associated fibroblasts as a therapeutic strategy for breast cancer. |
| المؤلفون: |
Borzone, Francisco Raúl, Giorello, María Belén, Sanmartin, María Cecilia, Yannarelli, Gustavo, Martinez, Leandro Marcelo, Chasseing, Norma Alejandra |
| المصدر: |
British Journal of Pharmacology; Jan2024, Vol. 181 Issue 2, p238-256, 19p |
| مصطلحات موضوعية: |
MESENCHYMAL stem cells, BREAST cancer, BREAST, FIBROBLASTS, TUMOR microenvironment, VIRAL tropism, STEM cells |
| مستخلص: |
Breast cancer is the most common type of cancer and the leading cause of death among women. Recent evidence suggests that mesenchymal stromal/stem cells and cancer‐associated fibroblasts (CAFs) have an essential role in cancer progression, invasion and therapy resistance. Therefore, they are considered as highly promising future therapeutic targets against breast cancer. The intrinsic tumour tropism and immunomodulatory capacities of mesenchymal stromal/stem cells are of special relevance for developing mesenchymal stromal/stem cells‐based anti‐tumour therapies that suppress primary tumour growth and metastasis. In addition, the utilization of therapies that target the stromal components of the tumour microenvironment in combination with standard drugs is an innovative tool that could improve patients' response to therapies and their survival. In this review, we discuss the currently available information regarding the possible use of mesenchymal stromal/stem cells‐derived anti‐tumour therapies, as well as the utilization of therapies that target CAFs in breast cancer microenvironment. Finally, these data can serve as a guide map for future research in this field, ultimately aiding the effective transition of these results into the clinic. LINKED ARTICLES: This article is part of a themed issue on Cancer Microenvironment and Pharmacological Interventions. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.2/issuetoc [ABSTRACT FROM AUTHOR] |
|
Copyright of British Journal of Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder