التفاصيل البيبلوغرافية
| العنوان: |
Enamine N -Oxides: Design, Synthesis, and Function in Bioortho-gonal Reactions. |
| المؤلفون: |
Kang, Dahye, Kim, Justin |
| المصدر: |
Synlett; Jan2024, Vol. 35 Issue 2, p145-154, 10p |
| مصطلحات موضوعية: |
ENAMINES, DIELS-Alder reaction, ORGANIC chemistry, ELIMINATION reactions, EXERGONIC reactions, CHEMICAL amplification |
| مستخلص: |
This article explores the design, synthesis, and function of enamine N-oxides in bioorthogonal reactions. Bioorthogonal chemistry allows for the modification of biomacromolecules in biological contexts, and enamine N-oxides play a crucial role in mediating these reactions. The authors discuss the challenges and strategies involved in synthesizing enamine N-oxides and highlight their potential applications in various fields. They also introduce the concept of push-pull-activated alkynes for bioorthogonal hydroamination, explaining how these alkynes can be more reactive and stable in a biological context. The article concludes by discussing the potential applications of these reactions in bioconjugation and drug release. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
