التفاصيل البيبلوغرافية
| العنوان: |
The operational and financial impact of adding anaerobic screening of platelets. |
| المؤلفون: |
Rios, Jorge, Webb, Jonathan, Dy, Beth, Young, Pampee P. |
| المصدر: |
Transfusion; Jan2024, Vol. 64 Issue 1, p104-115, 12p |
| مصطلحات موضوعية: |
CUTIBACTERIUM acnes, BLOOD platelets, BACTERIAL contamination, BACTERIAL cultures, COMMERCIAL product testing |
| مصطلحات جغرافية: |
DURHAM (N.C.) |
| الشركة/الكيان: |
AMERICAN Red Cross |
| مستخلص: |
Background and Objectives: We evaluated the operational and safety impact of implementing anaerobic culture screening of apheresis and pooled platelets at the American Red Cross on the already established use of the aerobic culture screening of each donation performed no sooner than 24 h following collection. Materials and Methods: Platelets were screened for bacterial contamination with the BACT/ALERT 3D® (bioMérieux, Durham, NC) microbial detection testing system. The addition of anaerobic culture to the already existing aerobic culture resulted in sampling an additional 8–10 mL from each donation. Results: Implementation of anaerobic testing resulted in an approximate 3.5‐fold increased rate of False Positive BACT/ALERT alarms. There was a modest increase in the rate of True Positive alarms of 1.4‐fold with increased detection of Klebsiella and Propionibacterium species, including Cutibacterium acnes. In addition, there was an approximate 3.5‐fold increase rate of False Positives and a 13.5‐fold increase rate of Indeterminates, the majority (~57%) were due to Cutibacterium acnes. The combined costs and lost revenue associated with adding anaerobic screening increased by ~$1,000,000/year due to testing cost and product discards. Conclusion: The addition of anaerobic culture to aerobic culture to the original donation (without the introduction of sampling delay) resulted in a significant increase in the rate of alerts. The 40% increased rate of True Positive alarms may have modestly improved platelet safety. However, there was a disproportionate increase in the rate of False Positive and Indeterminate bacterial culture alarms, which added substantial cost and overall loss of platelet products. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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