التفاصيل البيبلوغرافية
| العنوان: |
A Chimeric Classical Insect-Specific Flavivirus Provides Complete Protection Against West Nile Virus Lethal Challenge in Mice. |
| المؤلفون: |
Zhang, Hong-Qing, Li, Na, Zhang, Zhe-Rui, Deng, Cheng-Lin, Xia, Han, Ye, Han-Qing, Yuan, Zhi-Ming, Zhang, Bo |
| المصدر: |
Journal of Infectious Diseases; 1/15/2024, Vol. 229 Issue 1, p43-53, 11p |
| مصطلحات موضوعية: |
WEST Nile virus, FLAVIVIRUSES, TYPE I interferons, INTERFERON receptors, AEDES albopictus |
| مستخلص: |
West Nile virus (WNV), an arthropod-borne flavivirus, can cause severe symptoms, including encephalitis, and death, posing a threat to public health and the economy. However, there is still no approved treatment or vaccine available for humans. Here, we developed a novel vaccine platform based on a classical insect-specific flavivirus (cISF) YN15-283-02, which was derived from Culicoides. The cISF-WNV chimera was constructed by replacing prME structural genes of the infectious YN15-283-02 cDNA clone with those of WNV and successfully rescued in Aedes albopictus cells. cISF-WNV was nonreplicable in vertebrate cells and nonpathogenic in type I interferon receptor (IFNAR)-deficient mice. A single-dose immunization of cISF-WNV elicited considerable Th1-biased antibody responses in C57BL/6 mice, which was sufficient to offer complete protection against lethal WNV challenge with no symptoms. Our studies demonstrated the potential of the insect-specific cISF-WNV as a prophylactic vaccine candidate to prevent infection with WNV. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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