التفاصيل البيبلوغرافية
| العنوان: |
Severity of white matter microstructural damage in a Brazilian relapsing-remitting multiple sclerosis cohort: A possible window to optimize treatment. |
| المؤلفون: |
Correia, Rafael, Corrêa, Diogo, Doring, Thomas, Theodoro, Carmem, Correia, Aline, Coelho, Valeria, Dib, João Gabriel, Marchiori, Edson, Alves Leon, Soniza V, Rueda Lopes, Fernanda C |
| المصدر: |
Neuroradiology Journal; Feb2024, Vol. 37 Issue 1, p60-67, 8p |
| مستخلص: |
Background: Multiple sclerosis (MS) is an important cause of acquired neurological disability in young adults, characterized by multicentric inflammation, demyelination, and axonal damage. Objective: The objective is to investigate white matter (WM) damage progression in a Brazilian MS patient cohort, using diffusion tensor imaging (DTI) post-processed by tract-based spatial statistics (TBSS). Methods: DTI scans were acquired from 76 MS patients and 37 sex-and-age matched controls. Patients were divided into three groups based on disease duration. DTI was performed along 30 non-collinear directions by using a 1.5T imager. For TBSS analysis, the WM skeleton was created, and a 5000 permutation-based inference with a threshold of p <.05 was used, to enable the identification of abnormalities in fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD). Results: Decreased FA and increased RD, MD, and AD were seen in patients compared to controls and a decreased FA and increased MD and RD were seen, predominantly after the first 5 years of disease, when compared between groups. Conclusion: Progressive WM deterioration is seen over time with a more prominent pattern after 5 years of disease onset, providing evidence that the early years might be a window to optimize treatment and prevent disability. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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