التفاصيل البيبلوغرافية
| العنوان: |
UK NEQAS and BSHI guideline: Laboratory testing and clinical interpretation of HLA genotyping results supporting the diagnosis of coeliac disease. |
| المؤلفون: |
Pritchard, Deborah, Anand, Arthi, De'Ath, Amy, Lee, Helena, Rees, Margaret Tracey |
| المصدر: |
International Journal of Immunogenetics; Jan2024 Supplement 1, Vol. 51, p3-20, 18p |
| مصطلحات موضوعية: |
CELIAC disease, DIAGNOSIS, PATHOLOGICAL laboratories, TESTING laboratories, TEST interpretation, HETERODIMERS, GLUTEN |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
Coeliac disease is a common immune‐mediated inflammatory disorder caused by dietary gluten in genetically susceptible individuals. While the diagnosis of coeliac disease is based on serological and histological criteria, HLA‐DQ genotyping can be useful, especially in excluding the diagnosis in patients who do not carry the relevant DQ heterodimers: DQA1*05 DQB1*02, DQB1*03:02 or DQA1*02 DQB1*02 (commonly referred to as DQ2.5, DQ8 and DQ2.2, respectively). External quality assessment results for HLA genotyping in coeliac disease have revealed concerning errors in HLA genotyping, reporting and clinical interpretation. In response, these guidelines have been developed as an evidence‐based approach to guide laboratories undertaking HLA genotyping for coeliac disease and provide recommendations for reports to standardise and improve the communication of results. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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