التفاصيل البيبلوغرافية
| العنوان: |
Organophotocatalyzed Alkyl/Arylsulfonylation of Vinylcyclopropanes. |
| المؤلفون: |
Chandu, Palasetty, Mallick, Manasi, Srinivasu, Vinjamuri, Sureshkumar, Devarajulu |
| المصدر: |
Chemistry - A European Journal; Jan2024, Vol. 30 Issue 5, p1-6, 6p |
| مصطلحات موضوعية: |
VINYLCYCLOPROPANES, SULFONE derivatives, BIOACTIVE compounds, SULFINATES, PHARMACOPHORE, SODIUM salts, SULFONES |
| مستخلص: |
Allyl sulfones are an essential pharmacophore in many bioactive compounds. To combat their synthetic barrier, we report a practical, straightforward organophotocatalyzed methodology for accessing miscellaneously functionalized allyl sulfone derivatives using inexpensive and bench‐stable sodium sulfinate salts under mild conditions. This photo‐catalyzed radical sulfonylation provides access to a variety of allyl sulfones in good to excellent yields with high E : Z selectivity. A wide range of vinyl cyclopropanes, as well as aryl/hetero and alkyl sodium sulfinates, were tolerated and reliable in gram‐scale synthesis. Later on, further functionalization of allyl sulfones was demonstrated. A plausible mechanism for radical sulfonylation is proposed from the control experiments. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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