التفاصيل البيبلوغرافية
| العنوان: |
University of Siena Researchers Have Published New Data on Chronic Lymphocytic Leukemia (p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation). |
| المصدر: |
Hematology Week; 2/5/2024, p1898-1898, 1p |
| مصطلحات موضوعية: |
CHRONIC lymphocytic leukemia, SYNAPTOGENESIS, PROGRAMMED death-ligand 1, RESEARCH personnel, MONONUCLEAR leukocytes, FLUDARABINE, ALEMTUZUMAB |
| مستخلص: |
A new study conducted by researchers at the University of Siena in Italy explores the molecular mechanisms underlying chronic lymphocytic leukemia (CLL) and its ability to evade the immune system. The study focuses on the role of p66Shc deficiency in CLL cells, which leads to an impairment in intracellular reactive oxygen species (ROS) production and the overexpression of the inhibitory ligand PD-L1. The researchers found that the increase in PD-L1 expression prevents leukemic cells from forming immune synapses with T lymphocytes, thereby suppressing T cell-mediated anti-tumoral activities. These findings provide insight into the immunosuppressive nature of CLL and may have implications for the development of targeted therapies. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
