التفاصيل البيبلوغرافية
| العنوان: |
Meningioma-Induced Hyperostosis Is Associated with TRAF7 Gain-of-Function Missense Mutation in Primary Patient-Derived Meningioma Cells. |
| المؤلفون: |
Eaton, Charlotte D., Goldschmidt, Ezequiel, Chen, Zhenhong, Young, Jacob S., Raleigh, David R. |
| المصدر: |
Journal of Neurological Surgery. Part B. Skull Base; 2024 Supplement, Vol. 85, pS1-S398, 398p |
| مصطلحات موضوعية: |
MISSENSE mutation, GAIN-of-function mutations, MENINGIOMA, EXOSTOSIS |
| مستخلص: |
This article explores the mechanisms underlying meningioma-induced hyperostosis, a condition where tumors can form lamellar, hyperostotic bone in the tumor microenvironment. The study focuses on TRAF7 missense mutations, which are believed to promote bone formation in the meningioma microenvironment. The researchers used patient-derived meningioma cells and osteoblasts to investigate the biochemical mechanisms driving hyperostosis. They found that the TRAF7 missense mutation identified in a hyperostotic sphenoid wing meningioma contributed to the transdifferentiation of meningioma cells into osteoblast-like cells, leading to hyperostosis. These findings may have implications for the development of new medical therapies or the discovery of novel pathways of bone formation. [Extracted from the article] |
|
Copyright of Journal of Neurological Surgery. Part B. Skull Base is the property of Thieme Medical Publishing Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
