التفاصيل البيبلوغرافية
| العنوان: |
Yet another in vitro evidence that natural compounds introduced by diet have anti-amyloidogenic activities and can counteract neurodegenerative disease depending on aging. |
| المؤلفون: |
Asti, Anna Lia, Crespi, Stefania, Rampino, Teresa, Zelini, Paola, Gregorini, Marilena, Pascale, Alessia, Marchesi, Nicoletta, Saccucci, Stefania, Colombani, Carla, Vitalini, Sara, Iriti, Marcello |
| المصدر: |
Natural Product Research; 2024, Vol. 38 Issue 5, p861-866, 6p |
| مصطلحات موضوعية: |
NEURODEGENERATION, GALLIC acid, ALZHEIMER'S disease, X-ray microanalysis, TRANSMISSION electron microscopy |
| مستخلص: |
A major issue in Alzheimer's disease (AD) research is to find some new therapeutic drug which decrease Amyloid-beta (Aβ) aggregation. From a therapeutic point of view the major question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease. Natural compounds are capable of binding to different targets implicated in AD and exert neuroprotective effects. Aim of this study was to evaluate the in vitro inhibition of Aβ1-42 fibrillogenesis in presence of Gallic acid, Rutin, Melatonin and ProvinolsTM. We performed the analysis with Transmission and Scanning Electron Microscopy, and with X-ray microanalysis. Samples treated with Rutin, that arises from phenylalanine via the phenylpropanoid pathway, show the best effective result obtained because a significantly fibril inhibition activity is detectable compared to the other compounds. Melatonin shows a better inhibitory activity than ProvinolsTM and Gallic acid at the considered concentrations. [ABSTRACT FROM AUTHOR] |
|
Copyright of Natural Product Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
PDF full text from Publisher 
Full Text Finder