التفاصيل البيبلوغرافية
| العنوان: |
Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons. |
| المصدر: |
Mental Health Weekly Digest; 2/23/2024, p1269-1269, 1p |
| مصطلحات موضوعية: |
SCHIZOPHRENIA, NEURONS, SYNAPTOGENESIS, INTRACELLULAR space, CELL anatomy |
| مستخلص: |
A recent preprint abstract discusses the role of the schizophrenia risk gene ZNF804A in the development of human neurons. The study used induced pluripotent stem cells to investigate the gene's function during neurodevelopment. The researchers found that reduced expression of ZNF804A led to increased excitatory synapse density in mutant neurons. Additionally, proteomic analysis revealed higher levels of ribosomal and translational proteins in mutant neurons, suggesting that ZNF804A regulates excitatory synapse formation potential through increased local protein translation. It is important to note that this preprint has not yet undergone peer review. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
