التفاصيل البيبلوغرافية
| العنوان: |
Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system. |
| المؤلفون: |
Bhore, Noopur, Bogacki, Erin C., O'Callaghan, Benjamin, Plun-Favreau, Helene, Lewis, Patrick A., Herbst, Susanne |
| المصدر: |
Philosophical Transactions of the Royal Society B: Biological Sciences; 4/8/2024, Vol. 379 Issue 1899, p1-14, 14p |
| مصطلحات موضوعية: |
PARKINSON'S disease, GENOME-wide association studies, NEUROLOGICAL disorders, GENETIC disorders, IDENTIFICATION |
| مستخلص: |
Parkinson's disease is a progressive neurological disorder, characterized by prominent movement dysfunction. The past two decades have seen a rapid expansion of our understanding of the genetic basis of Parkinson's, initially through the identification of monogenic forms and, more recently, through genome-wide association studies identifying common risk variants. Intriguingly, a number of cellular pathways have emerged from these analysis as playing central roles in the aetiopathogenesis of Parkinson's. In this review, the impact of data deriving from genome-wide analyses for Parkinson's upon our functional understanding of the disease will be examined, with a particular focus on examples of endo-lysosomal and mitochondrial dysfunction. The challenges of moving from a genetic to a functional understanding of common risk variants for Parkinson's will be discussed, with a final consideration of the current state of the genetic architecture of the disorder. This article is part of a discussion meeting issue 'Understanding the endo-lysosomal network in neurodegeneration'. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
