التفاصيل البيبلوغرافية
| العنوان: |
Suppressor cell defect in SLE: relationship to native DNA binding. |
| المؤلفون: |
Krakauer, R. S., Clough, J. D., Alexander, J. D., Sundeen, J., Sauder, D. N. |
| المصدر: |
Clinical & Experimental Immunology; Apr1980, Vol. 40 Issue 1, p72-76, 5p |
| مصطلحات موضوعية: |
SUPPRESSOR cells, SYSTEMIC lupus erythematosus, DNA, T cells, LYMPHOCYTES, IMMUNOGLOBULINS |
| مستخلص: |
Recent evidence suggests the presence of a suppressor T cell defect in systemic lupus erythematosus. We confirm the presence of such a defect and find a strong quantitative correlation between the loss of suppressor T cell function and the activity of SLE as measured by the presence of antibodies to native DNA. In addition, the serum of patients with active SLE contains a soluble factor which when incubated with normal peripheral blood lymphocytes induces a suppressor T cell defect. These data are consistent with the suppressor cell defect being involved in the propagation and possibly the pathogenesis of SLE, and suggests a positive feedback mechanism whereby a suppressor cell defect results in autoantibodies including antibody to suppressor cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
