التفاصيل البيبلوغرافية
| العنوان: |
Nail psoriasis in China: A prospective multicentre study. |
| المؤلفون: |
Wang, Shiqi, Zhu, Jianjian, Wang, Ping, Dong, Jing, Li, Yanling, Shi, Dongmei, Wang, Huiping, Huang, Xi, Zhang, Xibao, Yu, Bo, Yang, Ziliang, Chen, Rixin, Wang, Xiaopeng, Li, Fuqiu, Bian, Kunpeng, Huo, Yuping, Yu, Nan, Li, Chen, Xia, Xiujuan, Lu, Jiejie |
| المصدر: |
Journal of the European Academy of Dermatology & Venereology; Mar2024, Vol. 38 Issue 3, p549-556, 8p |
| مصطلحات موضوعية: |
NAIL diseases, NAILS (Anatomy), BODY surface area, BODY mass index, LONGITUDINAL method, TOENAILS |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
Background: Data on nail psoriasis (PsO) in China are scarce. Objectives: To provide nail PsO‐related data regarding epidemiologic characteristics, manifestations, fungal infections, arthritic complaints and treatments that may facilitate improved patient management globally. Methods: From August 2021 to August 2022, patients with nail PsO were enrolled in a prospective multicentre observational study at 25 hospitals in China. We collected and analysed data concerning nail PsO demography, clinical signs, fungal detection, arthritic symptoms and treatment. Results: A total of 817 patients with nail PsO were involved, with a mean body mass index of 24.13 ± 2.93. In addition, 71.41% of the patients were male. The Nail PsO Severity Index score was weakly positively correlated with body surface area. The percentage of nail involvement was 95.29% for fingernails and 57.18% for toenails, with pitting (67.11%) and subungual hyperkeratosis (60.40%) being the most prevalent manifestations, respectively. Toenails showed a significantly higher frequency of nailfold scales, subungual hyperkeratosis and nail plate crumbling and a lower frequency of splinter haemorrhages, pitting and erythema of the lunula. A total of 13.26% of the PsO patients had onychomycosis, and 77.08% were observed in the toenails. Articular symptoms were reported by 12.17% of the patients, with the peripheral type being predominant. Significant associations between articular symptoms and nailfold swelling, subungual hyperkeratosis, nailfold scales, onycholysis and longitudinal ridges were found. Only 2.30% (20 out of 871) of patients with nail PsO received treatment. The most frequently employed therapy for cutaneous PsO with nail involvement was biologic therapy (n = 366). Conclusions: PsO showed distinct manifestations in the toenails and fingernails. Additionally, toenail PsO combined with onychomycosis requires special attention. Articular symptoms in psoriatic patients are associated with specific nail changes. It is important to research and advocate for more potent treatments for nail PsO. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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