التفاصيل البيبلوغرافية
| العنوان: |
Utility of Rapid Nasopharyngeal Swab for Respiratory Pathogens in the Diagnosis of Viral Infections in Children Hospitalized with Fever: A Prospective Validation Study to Improve Antibiotic Use. |
| المؤلفون: |
Buonsenso, Danilo, Morello, Rosa, Mariani, Francesco, Mazzoli, Bianca, De Rose, Cristina, Lazzareschi, Ilaria, Raffaelli, Francesca, Blandino, Rita, Sanguinetti, Maurizio, Valentini, Piero |
| المصدر: |
Children; Feb2024, Vol. 11 Issue 2, p225, 13p |
| مصطلحات موضوعية: |
VIRUS disease drug therapy, DIAGNOSIS of bacterial diseases, NASOPHARYNX microbiology, VIRAL disease diagnosis, ANTIBIOTICS, KRUSKAL-Wallis Test, FEVER, PREDICTIVE tests, ACADEMIC medical centers, CAREGIVERS, URINARY tract infections, POINT-of-care testing, RAPID diagnostic tests, RESPIRATORY infections, DIFFERENTIAL diagnosis, FISHER exact test, MANN Whitney U Test, RESPIRATORY organ sounds, T-test (Statistics), COMPARATIVE studies, QUALITY assurance, COUGH, CHI-squared test, DESCRIPTIVE statistics, DRUG utilization, BACTERIAL diseases, SENSITIVITY & specificity (Statistics), DATA analysis software, HOSPITAL care of children, LONGITUDINAL method, ALGORITHMS, SYMPTOMS, CHILDREN |
| مصطلحات جغرافية: |
ITALY |
| مستخلص: |
Introduction: Fever is among the most common reason for medical assessment and antibiotic prescription in practice. The aim of this study was to evaluate positive and negative predictive values of rapid nasopharyngeal swabs for respiratory pathogens to discriminate viral from bacterial infections. Methods: We prospectively tested children with signs and/or symptoms of infections (e.g., fever, cough, wheezing, suspected urinary tract infection) admitted to a paediatric department. Following discharge, clinical phenotypes were assigned defining a cohort of children having probable/certain viral infection, probable/certain bacterial infection, other inflammatory conditions or healthy controls. Results: In this study, 190 children were enrolled (50.5% females, median age 30.5 (8–86) months). In total, 102 patients (53.7%) were affected by respiratory viral infections, 16 (8.4%) by bacterial infections, 29 (15.3%) were healthy controls and 43 (22.6%) were affected by another pathological condition manifested with fever. In total, 84.3% of patients classified as viral infection tested positive for viruses, compared with 18.8% of patients with bacterial infection (p < 0.001), 18.6% of patients with other condition (p < 0.001) and 17.2% of control patients (p < 0.001). The positive predictive value of NPSs in the diagnosis of viral infection was 88.6% and the negative predictive value was 75.0%. Conclusion: Our findings suggest that rapid NPS tests for respiratory viruses are a useful tool to confirm viral infections in children with fever and improve antibiotic use. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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