التفاصيل البيبلوغرافية
| العنوان: |
NEW BENZIMIDAZOLE 3'-DEOXYNUCLEOSIDES. |
| المؤلفون: |
ARNAUTOVA, Aleksanda O., ALEKSAKHINA, Irina A., KAYUSHIN, Alexey L., KONSTANTINOVA, Irina D. |
| المصدر: |
Journal of Research in Pharmacy; 2023 Supplement, Vol. 27, p57-57, 1p |
| مصطلحات موضوعية: |
BENZIMIDAZOLES, NUCLEOSIDES, CARBOHYDRATES, ANTIHISTAMINES |
| مستخلص: |
Compounds containing benzimidazole fragment exhibit pronounced antiviral, antispasmodic, neuroleptic, and antihistamine activity. The biological activity profileof benzimidazole nucleosides can be changed by introducing a substituent into the benzimidazole ring and/or carbohydrate residue. A series of new modified substituted benzimidazole nucleosides (3'd-Rib-Bm) has been prepared by enzymatic method with yields from 8 to 72% and with purity morethan 95%. 3'-Deoxyinosine (3'd-Ino) and substituted benzimidazoles (Bm) have been used as substrates in the transglycosylation reaction in the presence of recombinant purine nucleoside phosphorylase (PNP). At the first step, each reaction was optimized for substrate ratio and amount of PNP. Conditions: 50 ℃, 2 mM potassium-phosphate buffer, pH 7.0. The next step was preparative synthesis followed by isolation of enzymatic reaction products. Thestructures of 3'd-Rib-Bm were confirmed by NMR and mass-spectrometry. In the case of asymmetrically substituted benzimidazoles N1 and N3 regio-isomers were formed. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Research in Pharmacy is the property of Marmara University, Faculty of Pharmacy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder