التفاصيل البيبلوغرافية
| العنوان: |
Insulin Secretion, Sensitivity, and Kidney Function in Young Individuals With Type 2 Diabetes. |
| المؤلفون: |
Bjornstad, Petter, Choi, Ye Ji, Platnick, Carson, Gross, Susan, Narongkiatikhun, Phoom, Melena, Isabella, Remmers, Lauryn, Baca, Madison, Schutte, Grant, Dobbs, Tyler, Vigers, Tim, Pyle, Laura, Driscoll, Lynette, Tommerdahl, Kalie, Kendrick, Jessica, Looker, Helen C., Dart, Allison, Cherney, David, van Raalte, Daniel H., Srivastava, Anand |
| المصدر: |
Diabetes Care; Mar2024, Vol. 47 Issue 3, p409-417, 9p |
| مصطلحات موضوعية: |
TYPE 2 diabetes, KIDNEY physiology, GLUCOSE clamp technique, SECRETION, BODY composition, PLASMA flow |
| مستخلص: |
OBJECTIVE: β-Cell dysfunction and insulin resistance magnify the risk of kidney injury in type 2 diabetes. The relationship between these factors and intraglomerular hemodynamics and kidney oxygen availability in youth with type 2 diabetes remains incompletely explored. RESEARCH DESIGN AND METHODS: Fifty youth with type 2 diabetes (mean age ± SD 16 ± 2 years; diabetes duration 2.3 ± 1.8 years; 60% female; median HbA1c 6.4% [25th, 75th percentiles 5.9, 7.6%]; BMI 36.4 ± 7.4 kg/m2; urine albumin-to-creatinine ratio [UACR] 10.3 [5.9, 58.0] mg/g) 21 control participants with obesity (OCs; age 16 ± 2 years; 29% female; BMI 37.6 ± 7.4 kg/m2), and 20 control participants in the normal weight category (NWCs; age 17 ± 3 years; 70% female; BMI 22.5 ± 3.6 kg/m2) underwent iohexol and p-aminohippurate clearance to assess glomerular filtration rate (GFR) and renal plasma flow, kidney MRI for oxygenation, hyperglycemic clamp for insulin secretion (acute C-peptide response to glucose [ACPRg]) and disposition index (DI; ×103 mg/kg lean/min), and DXA for body composition. RESULTS: Youth with type 2 diabetes exhibited lower DI (0.6 [0.0, 1.6] vs. 3.8 [2.4, 4.5] × 103 mg/kg lean/min; P < 0.0001) and ACPRg (0.6 [0.3, 1.4] vs. 5.3 [4.3, 6.9] nmol/L; P < 0.001) and higher UACR (10.3 [5.9, 58.0] vs. 5.3 [3.4, 14.3] mg/g; P = 0.003) and intraglomerular pressure (77.8 ± 11.5 vs. 64.8 ± 5.0 mmHg; P < 0.001) compared with OCs. Youth with type 2 diabetes and OCs had higher GFR and kidney oxygen availability (relative hyperoxia) than NWCs. DI was associated inversely with intraglomerular pressure and kidney hyperoxia. CONCLUSIONS: Youth with type 2 diabetes demonstrated severe β-cell dysfunction that was associated with intraglomerular hypertension and kidney hyperoxia. Similar but attenuated findings were found in OCs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
