التفاصيل البيبلوغرافية
| العنوان: |
Screening for pre‐eclampsia with competing‐risks model using placental growth factor measurement in blood samples collected before 11 weeks' gestation. |
| المؤلفون: |
Riishede, I., Ekelund, C. K., Sperling, L., Overgaard, M., Knudsen, C. S., Clausen, T. D., Pihl, K., Zingenberg, H. J., Wright, A., Wright, D., Tabor, A., Rode, L., Andersen, M. R., Bendix, E. J., Gjerris, A. C., Hillig, T., Jakobsen, T. R., Jørgensen, F. S., Munk, J. K., Sandager, P. |
| المصدر: |
Ultrasound in Obstetrics & Gynecology; Mar2024, Vol. 63 Issue 3, p342-349, 8p |
| مصطلحات موضوعية: |
PLACENTAL growth factor, MEDICAL screening, BLOOD sampling, OBSTETRICS, PREECLAMPSIA |
| الشركة/الكيان: |
JOHN Wiley & Sons Inc. |
| مستخلص: |
Objectives: To describe the distributional properties and assess the performance of placental growth factor (PlGF) measured in blood samples collected before 11 weeks' gestation in the prediction of pre‐eclampsia (PE). Methods: The study population consisted of pregnant women included in the Pre‐eclampsia Screening in Denmark (PRESIDE) study with a PlGF measurement from the routine combined first‐trimester screening (cFTS) blood sample collected at 8–14 weeks' gestation. PRESIDE was a prospective multicenter study investigating the predictive performance of the Fetal Medicine Foundation (FMF) first‐trimester screening algorithm for PE in a Danish population. In the current study, serum concentration of PlGF in the cFTS blood samples was analyzed in batches between January and June 2021. Results: A total of 8386 pregnant women were included. The incidence of PE was 0.7% at < 37 weeks' gestation and 3.0% at ≥ 37 weeks. In blood samples collected at 10 weeks' gestation, PlGF multiples of the median (MoM) were significantly lower in pregnancies with preterm PE < 37 weeks compared to unaffected pregnancies. However, PlGF MoM did not differ significantly between pregnancies with PE and unaffected pregnancies in samples collected before 10 weeks' gestation. Conclusions: The gestational‐age range for PlGF sampling may be expanded from 11–14 to 10–14 weeks when assessing the risk for PE using the FMF first‐trimester screening model. There is little evidence to support the use of PlGF in blood samples collected before 10 weeks' gestation. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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