التفاصيل البيبلوغرافية
| العنوان: |
Demographics and additional haematologic cancers of patients with histiocytic/dendritic cell neoplasms. |
| المؤلفون: |
Kemps, Paul G, Kester, Lennart, Scheijde‐Vermeulen, Marijn A, van Noesel, Carel J M, Verdijk, Robert M, Diepstra, Arjan, van Marion, Ariënne M W, Dors, Natasja, van den Bos, Cor, Bruggink, Annette H, Hogendoorn, Pancras C W, van Halteren, Astrid G S |
| المصدر: |
Histopathology; Apr2024, Vol. 84 Issue 5, p837-846, 10p |
| مصطلحات موضوعية: |
DEMOGRAPHIC characteristics, DENDRITIC cells, LANGERHANS-cell histiocytosis, CANCER patients, TUMORS, RETICULUM cell sarcoma |
| مصطلحات جغرافية: |
NETHERLANDS |
| مستخلص: |
Aims: The discovery of somatic genetic alterations established many histiocytic disorders as haematologic neoplasms. We aimed to investigate the demographic characteristics and additional haematologic cancers of patients diagnosed with histiocytic disorders in The Netherlands. Methods and results: We retrieved data on histiocytosis patients from the Dutch Nationwide Pathology Databank (Palga). During 1993 to 2022, more than 4000 patients with a pathologist‐assigned diagnosis of a histiocytic disorder were registered in Palga. Xanthogranulomas were the most common subtype, challenging the prevailing assumption that Langerhans cell histiocytosis (LCH) is the most common histiocytic disorder. LCH and juvenile xanthogranuloma (JXG) had a peak incidence in the first years of life; males were overrepresented among all histiocytosis subgroups. 118 patients had a histiocytic disorder and an additional haematologic malignancy, including 107 (91%) adults at the time of histiocytosis diagnosis. In 16/118 patients, both entities had been analysed for the same genetic alteration(s). In 11 of these 16 patients, identical genetic alterations had been detected in both haematologic neoplasms. This included two patients with PAX5 p.P80R mutated B cell acute lymphoblastic leukaemia and secondary histiocytic sarcoma, further supporting that PAX5 alterations may predispose (precursor) B cells to differentiate into the myeloid lineage. All 4/11 patients with myeloid neoplasms as their additional haematologic malignancy had shared N/KRAS mutations. Conclusions: This population‐based study highlights the frequency of xanthogranulomas. Furthermore, our data add to the growing evidence supporting clonal relationships between histiocytic/dendritic cell neoplasms and additional myeloid or lymphoid malignancies. Particularly adult histiocytosis patients should be carefully evaluated for the development of these associated haematologic cancers. [ABSTRACT FROM AUTHOR] |
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