التفاصيل البيبلوغرافية
| العنوان: |
Association between albumin-corrected anion gap and in-hospital mortality of intensive care patients with trauma: A retrospective study based on MIMIC-Ⅲ and Ⅳ databases. |
| المؤلفون: |
Yin, Fei, Qiao, Zhenguo, Wu, Xiaofei, Shi, Qiang, Jin, Rongfei, Xu, Yuzhou |
| المصدر: |
PLoS ONE; 3/7/2024, Vol. 19 Issue 3, p1-18, 18p |
| مصطلحات موضوعية: |
TRAUMA registries, HOSPITAL mortality, INTENSIVE care patients, RECEIVER operating characteristic curves, PROPENSITY score matching, LOG-rank test |
| مستخلص: |
Background: To investigate the correlation between albumin-corrected anion gap(ACAG) within the first 24 hours of admission and in-hospital mortality in trauma patients in intensive care unit(ICU). Materials and methods: We utilized the MIMIC-Ⅲ and MIMIC-Ⅳ databases to examine trauma patients admitted to the ICU. The relationship between ACAG and in-hospital mortality in trauma patients was analyzed using Receiver Operating Characteristic(ROC) curve, Kaplan-Meier (K-M) survival curve, and Cox regression model. Propensity score matching (PSM) and subgroup analysis were conducted to enhance stability and reliability of the findings. Mortality at 30-day and 90-day served as secondary outcomes. Results: The study enrolled a total of 1038 patients. The AUC for ACAG (0.701, 95%CI: 0.652–0.749) was notably higher than that for anion gap and albumin. The Log-rank test revealed that the optimal cut-off point of ACAG for predicting in-hospital mortality was determined to be 20.375mmol/L. The multivariate Cox regression analysis demonstrated an independent association between high ACAG level and a higher risk of in-hospital mortality (HR = 3.128, 95% CI: 1.615–6.059). After PSM analysis, a matched cohort consisting of 291 subjects was obtained. We found no signifcant interaction in most stratas. Finally, The in-hospital, 30-day, and 90-day survival rates in the high ACAG group exhibited a statistically decrease compared to those in the low ACAG group both pre- and post-matching. Conclusion: The elevated level of ACAG was found to be independently associated with increased in-hospital mortality among trauma patients in the ICU. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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