التفاصيل البيبلوغرافية
| العنوان: |
Skull-Base Chondrosarcoma: A Systematic Review of the Role of Postoperative Radiotherapy. |
| المؤلفون: |
Ravindran, Pawan Kishore, Keizer, Max E., Kunst, Henricus P. M., Compter, Inge, Van Aalst, Jasper, Eekers, Daniëlle B. P., Temel, Yasin |
| المصدر: |
Cancers; Mar2024, Vol. 16 Issue 5, p856, 22p |
| مصطلحات موضوعية: |
MEDICAL information storage & retrieval systems, CHONDROSARCOMA, RADIOTHERAPY, CANCER relapse, DESCRIPTIVE statistics, SYSTEMATIC reviews, MEDLINE, KAPLAN-Meier estimator, SKULL tumors, MEDICAL databases, ONLINE information services, DISEASE relapse, PROGRESSION-free survival, CONFIDENCE intervals, DATA analysis software, QUALITY assurance |
| مستخلص: |
Simple Summary: Currently, there is no global consensus regarding the treatment of skull-base chondrosarcoma. Some believe surgery is sufficient, while others administer adjuvant radiotherapy regardless of the extent of surgical resection. This review aims to gather the latest available evidence regarding the treatment of skull-base chondrosarcoma and to analyze the long-term prognosis to ascertain the potential added value of adjuvant radiotherapy and its application. Surgery and radiotherapy are key elements to the treatment of skull-base chondrosarcomas; however, there is currently no consensus regarding whether or not adjuvant radiotherapy has to be administered. This study searched the EMBASE, Cochrane, and PubMed databases for clinical studies evaluating the long-term prognosis of surgery with or without adjuvant radiotherapy. After reviewing the search results, a total of 22 articles were selected for this review. A total of 1388 patients were included in this cohort, of which 186 received surgery only. With mean follow-up periods ranging from 39.1 to 86 months, surgical treatment provided progression-free survival (PFS) rates ranging from 83.7 to 92.9% at 3 years, 60.0 to 92.9% at 5 years, and 58.2 to 64.0% at 10 years. Postoperative radiotherapy provides PFS rates ranging between 87 and 96.2% at 3 years, 57.1 and 100% at 5 years, and 67 and 100% at 10 years. Recurrence rates varied from 5.3% to 39.0% in the surgery-only approach and between 1.5% and 42.90% for the postoperative radiotherapy group. When considering prognostic variables, higher age, brainstem/optic apparatus compression, and larger tumor volume prior to radiotherapy were found to be significant factors for local recurrence. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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